Sepsis profile and outcome of preterm neonates admitted to neonatal intensive care unit of Cairo University Hospital

Abstract Background This study demonstrates the experience of neonatal intensive care unit (NICU) a tertiary referral center in Egypt management prematures with sepsis. retrospective included preterm neonates admitted to NICU clinical and/or laboratory diagnosis Blood culture was done followed by antimicrobial susceptibility testing for positive cases. Neonates sepsis were classified into early onset (EOS) and late (LOS). Hematological scoring system (HSS) detection calculated. Results The 153 cases sepsis; 63 (41.2%) EOS 90 (58.8%) LOS. majority had very low or moderately birth weight (90.9%). All received first-line antibiotics form ampicillin-sulbactam, gentamicin. Second-line administered 133 (86.9%) as vancomycin imipenem-cilastatin. Mortalities more common among group ( p < 0.017). Positive blood cultures detected 61 (39.8%) total number 66 cultures. most commonly encountered organisms Klebsiella MDR CoNS (31.8% each). predominant organism (28.9%), while LOS (39.2%) divided 3 families; Enterobacteriaceae , non-fermenters, Gram-positive family. There families 100% resistant ampicillin. highest sensitivity Non-fermenters colistin polymyxin-B. An HSS 3–8 specificity 62.3% 57.6%, respectively culture-proven Conclusion Neonatal 21.5% neonates; (58.8%). Mortality 51.6%. both isolated hematological showed limited